窩客幫-分身行銷廣告平台

The human oral cavity hosts over ten thousand bacteria that digest sugars to form tenacious biofilms on teeth and periodontal tissues. Aerobic bacteria, such as Streptococcus mutans, erode tooth enamel by secreting acidic substances, leading to cavities. Meanwhile, anaerobic pathogens like Porphyromonas gingivalis release toxins that cause inflammation, bone damage, and bad breath. Since salivary immunoglobulin A (IgA) is critical for mucosal immunity and defending against these pathogens, there is a significant need for probiotic compositions that can effectively increase oral IgA levels and inhibit pathogen growth to maintain oral health.

The invention provides a method of increasing an amount of oral immunoglobulin A (IgA) and/or inhibiting oral pathogens in a subject in need thereof, which utilizes a composition including a therapeutically effective amount of probiotics as an effective ingredient. The probiotics include Lactobacillus plantarum LPL28, which can efficiently increase the amount of oral IgA and/or inhibit the oral pathogens, and thus have a potential to prevent teeth cavities and/or periodontal diseases.

人類口腔中存在上萬種細菌，會消化糖分並形成生物膜 。其中需氧菌（如變形鏈球菌）會產生酸性物質侵蝕琺瑯質導致蛀牙 ；厭氧菌（如牙齦卟啉單胞菌）則會釋放毒素引發牙周組織發炎、腫脹及口臭 。由於口腔黏膜防禦高度仰賴免疫球蛋白 A（IgA），因此研發能有效增加 IgA 並抑制病原菌的組合物對於強化口腔免疫至關重要。

本發明提供一種益生菌用於製備提升口腔免疫球蛋白A含量及抑制口腔病原菌之組成物的用途,其中此益生菌包含植物乳酸桿菌(Lactobacillus plantarum) LPL28做為有效成分,可有效提升口腔 IgA 含量及/或抑制口腔病原菌,而具有預防龋齒及/或牙周病的潛力。