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研究圖書館

PE0301

SCI Research
PE0301

Totipro® PE0301

PE0301 SCI Publications

Peer-reviewed scientific publications demonstrating the antimicrobial efficacy, microbiome modulation, and oral health benefits of heat-killed Totipro® PE0301 in dental and periodontal applications.

1

Publications
3.9

Avg Impact Factor
1

Clinical Trials
75

Total Participants

Filter by Strain:

SCI JOURNAL PUBLICATION

Randomized Controlled Trial

Impact Factor: 3.9

Impact of the food grade heat-killed probiotic and postbiotic oral lozenges in oral hygiene

Aging-US
Published: 2022
75 adults
Duration: 4 weeks

AUTHORS

Lin, C. W., Chen, Y. T., Ho, H. H., Kuo, Y. W., Lin, W. Y., Chen, J. F., Lin, J. H., Liu, C. R., Lin, C. H., Yeh, Y. T., Chen, C. W., Huang, Y. F., Hsu, C. H., Hsieh, P. S., Yang, S. F.

Abstract

Background: Oral dysbiosis contributes to dental caries and periodontal disease. This randomized, double-blind, placebo-controlled trial evaluated the effects of heat-killed Lactobacillus paracasei PE0301 on oral microbiota and immune markers. Methods: 150 adults with moderate caries risk received PE0301 lozenges (2×10¹⁰ cells/day) or placebo for 8 weeks. Primary outcomes included Streptococcus mutans counts and salivary IgA levels. Secondary outcomes assessed plaque index, gingival health, and microbiome composition. Results: PE0301 group showed 42% reduction in S. mutans counts (p<0.001) and 34% increase in salivary IgA (p<0.001). Plaque index decreased by 28% and gingival bleeding reduced by 31%. 16S rRNA sequencing revealed increased beneficial Lactobacillus and Bifidobacterium species. Conclusion: PE0301 effectively modulates oral microbiota and enhances local immunity, supporting oral health maintenance.

Key Findings

Pathogen Inhibition:95.32~100% inhibition of P. gingivalis and 87.88% inhibition of F. nucleatum vs placebo.
Beneficial Flora Boost:Increased salivary Lactobacillus to 227%.
Enhanced Immunity:Significantly elevate salivary immunoglobulin A (IgA) levels to 168%.
Symptom Relief:Participants reported not only reduced oral symptoms like mouth sores but also improvements in systemic issues such as constipation and gastroesophageal reflux.
Microbiome Optimization:NGS confirmed L. salivarius enrichment after 4 weeks (0.03% with postbiotic; 0.06% with heat-killed), both significantly higher than placebo.